TRV055
Catalogue number:
HY-P3136-10mg
Supplier:
Size:
10 mg
Product is available in:
CAS Number:
25849-90-5
Purity:
99.75
Molecular Weight:
831.96
Alternative Names:
TRV120055
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Product Description:
TRV055 (TRV120055) is a G protein-biased agonist of angiotensin II type 1 receptors (AT1Rs). TRV120055 induces fibroblast proliferation, overexpression of collagen I and α-SMA, and stress fibre formation in human cardiac fibroblasts. TRV055 activates AT1 receptor/Gαq-mediated signaling pathways, upregulates TGF-β1 and p-ERK1/2. TRV055 induces collagen secretion in adult rat myofibroblasts at a level comparable to Ang II. TRV055 can be used to study the role of G protein-biased signaling of AT1Rs in regulating fibrotic responses[1][2].