P5(PEG24)-VC-PAB-Exatecan

Name: P5(PEG24)-VC-PAB-Exatecan
Brand: MedChem Express
SKU: CBSKU_201661312
Price: 1449 GBP
Availability: InStock

Catalogue number:

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HY-163099-1mg

Supplier:

MedChem Express

Size:

1 mg

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£1449.00

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This product is for research use only and is not for human consumption or therapeutic use.

Molecular Formula:

C100H151FN9O36P

Molecular Weight:

2105.28

Data sheet: View or download
MSDS: View or download
Protocol: View or download

Product Description:

P5 (PEG24)-VC-PAB-Exatecan is a TOP1 inhibitor payload with antibody-conjugation-dependent activity. Conjugation of P5 (PEG24)-VC-PAB-Exatecan with Trastuzumab (HY-P9907) generates a DAR8 antibody-drug conjugate (ADCs) with antibody-like pharmacokinetic properties. P5 (PEG24)-VC-PAB-Exatecan induces S-phase and G2-M-phase cell cycle arrest, DNA damage and apoptosis in target-positive tumor cells, and releases damage-associated molecular patterns (DAMP) related to immunogenic cell death (ICD). The ADCs prepared from it exert bystander killing effects on non-target tumor cells. ADCs based on P5 (PEG24)-VC-PAB-Exatecan exhibit linker stability in vitro and in vivo, show in vivo efficacy, and can be used in research related to HER2-positive cancers[1].