PROTAC EGFR degrader 7 (diTFA)
Catalogue number:
HY-147858A-100mg
Supplier:
Size:
100 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
Purity:
99.19
Molecular Formula:
C50H50F6N10O10
Molecular Weight:
1064.98
Mass Spectrometry:
Reference Materials
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
PROTAC EGFR degrader 7 (compound 13b) is a potent and selective CRBN-recruiting PROTAC EGFRL858R/T790M degrader, with a DC50 of 13[1].2 nM.PROTAC EGFR degrader 7 inhibits NCI-H1975 cells proliferation, with an IC50 of 46[1].82 nM.PROTAC EGFR degrader 7 significantly induces apoptosis and G2/M phase arrest in NCI-H1975 cell.PROTAC EGFR degrader 7 shows antitumor activity, and can be used for non-small cell lung cancer (NSCLC) research[1].