RK-9123016
Catalogue number:
HY-111522-10mg
Supplier:
Size:
10 mg
Product is available in:
£93.00
Special price until 31 Dec 2025
Normal price £103.00
Shipping is calculated in checkout
Normal price £103.00
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
955900-27-3
Mass Spectrometry:
Reference Materials
- Data sheet: View or download
- MSDS: View or download
Product Description:
RK-9123016 is a potent inhibitor of SIRT2. RK-9123016 inhibits the enzymatic activity of SIRT2 with an IC50 value of 0.18 µM but not other human sirtuin members including SIRT1 and SIRT3 at 100 µM. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of SIRT2, and reduces cell viability of human breast cancer cells accompanied with a decrease in c-Myc expression[1].