GNE-7883
Catalogue number:
HY-147214-5mg
Supplier:
Size:
5 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2648450-42-2
Purity:
99.54
Molecular Formula:
C28H29FN6O2
Molecular Weight:
500.57
Mass Spectrometry:
Reference Materials
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
GNE-7883 is a pan-TEAD inhibitor that blocks the association of YAP/TAZ with TEAD. GNE-7883 effectively reduces chromatin accessibility at TEAD motifs, inhibits cell proliferation in multiple cell line models, and achieves strong anti-tumor efficacy in vivo. In addition, GNE-7883 effectively overcomes intrinsic and acquired resistance to KRAS (Kirsten rat sarcoma viral oncogene homolog) G12C inhibitors in multiple preclinical models by inhibiting YAP/TAZ activation[1][2][3].