This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2098211-50-6
Purity:
99.75
Molecular Formula:
C26H23F3N6O
Molecular Weight:
492.50
Mass Spectrometry:
Reference Materials
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
I-138 is an orally active, reversible inhibitor of USP1-UAF1 (IC50: 4.1 nM; Ki: 5.4 nM), structurally related to ML323 (HY-17543). I-138 induces monoubiquitination of FANCD2 and PCNA in cells and eliminates USP1 autocleavage in cells[1].