Bemcentinib
Catalogue number:
HY-15150-5mg
Supplier:
Size:
5 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1037624-75-1
Purity:
99.92
Molecular Formula:
C30H34N8
Molecular Weight:
506.64
Mass Spectrometry:
Reference Materials
Alternative Names:
R428; BGB324
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Bemcentinib (R428) is a selective and orally active Axl inhibitor with an IC50 of 14 nM. Bemcentinib retards cancer cell migration and invasion. Bemcentinib exhibits >100-fold selectivity for Axl versus Abl and 50- and >100-fold selectivity over TAM family kinases Mer and Tyro3, respectively, in cells. Bemcentinib blocks tumor spread and prolongs survival in models of metastatic breast cancer[1][2].