SIRT1, Human (His)

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SIRT1 is an NAD-dependent protein deacetylase that integrates multiple cellular functions—cell cycle progression, DNA damage response, metabolism, apoptosis, and autophagy—by regulating the acetylation of various target proteins.SIRT1 responds to changes in the NAD(+)/NADH ratio caused by factors such as glucose deprivation, affecting chromatin remodeling through histone deacetylation, resulting in transcriptional regulation. SIRT1 Protein, Human (His) is the recombinant human-derived SIRT1 protein, expressed by E.coli , with N-6*His labeled tag.