Semapimod (tetrahydrochloride)
Catalogue number:
HY-15509A-25mg
Supplier:
Size:
25 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
164301-51-3
Purity:
98.43
Molecular Formula:
C34H56Cl4N18O2
Molecular Weight:
890.74
Mass Spectrometry:
Reference Materials
Alternative Names:
CNI-1493; CPSI-2364 (tetrahydrochloride)
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- Protocol: View or download
Product Description:
Semapimod tetrahydrochloride (CNI-1493), an inhibitor of proinflammatory cytokine production, can inhibit TNF-α, IL-1β, and IL-6. Semapimod tetrahydrochloride inhibits TLR4 signaling (IC50≈0.3 µM). Semapimod tetrahydrochloride inhibits p38 MAPK and nitric oxide production in macrophages. Semapimod tetrahydrochloride has potential in a variety of inflammatory and autoimmune disorders[1][2][3].