Aleplasinin
Catalogue number:
HY-14759-10mg
Supplier:
Size:
10 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
481629-87-2
Purity:
99.59
Molecular Formula:
C28H27NO3
Molecular Weight:
425.52
Mass Spectrometry:
Reference Materials
Alternative Names:
PAZ-417
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Aleplastinin (PAZ-417) is an orally active, blood-brain barrier permeable, selective SERPINE1 (PAI-1) inhibitor (IC50=655 nM). Aleplastinin activates the tissue type plasminogen activator (tPA)/fibrinolysis cascade by inhibiting PAI-1, thereby promoting the degradation of amyloid-β (Aβ) oligomers and monomers. Aleplastinin can significantly reduce plasma and brain Aβ levels, improve memory impairment, and reverse cognitive impairment. Aleplastinin can be used for research on Alzheimer's disease[1][2].