JBJ-09-063 (TFA)
Catalogue number:
HY-147183A-100mg
Supplier:
Size:
100 mg
Product is available in:
£4581.00
Special price until 31 Dec 2025
Normal price £5089.00
Shipping is calculated in checkout
Normal price £5089.00
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
Purity:
99.64
Molecular Formula:
C33H30F4N4O5S
Molecular Weight:
670.67
Mass Spectrometry:
Reference Materials
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
JBJ-09-063 TFA is a mutant-selective allosteric EGFR inhibitor with IC50s of 0.147 nM, 0.063 nM, 0.083 nM and 0.396 nM for EGFR L858R, EGFR L858R/T790M, EGFR L858R/T790M/C797S and EGFRLT/L747S. JBJ-09-063 TFA effectively reduces EGFR, Akt and ERK1/2 phosphorylation. JBJ-09-063 TFA is effective across EGFR tyrosine kinase inhibitor (TKI)-sensitive and resistant models. JBJ-09-063 TFA can be used for researching EGFR-mutant lung cancer[1].