AGI-43192
Catalogue number:
HY-145777-25mg
Supplier:
Size:
25 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2377491-54-6
Purity:
99.47
Molecular Formula:
C23H16ClF3N6O
Molecular Weight:
484.86
Mass Spectrometry:
Reference Materials
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
AGI-43192 is a potent and orally active inhibitor of methionine adenosyltransferase 2A (MAT2A) that limitedly penetrates the blood-brain barrier. AGI-43192 exhibits inhibitory activitity against MAT2A and S-adenosyl methionine (SAM) in HCT-116 MTAP-null cells with IC50s of 32 and 14 nM. AGI-43192 can significantly inhibit the proliferation of HCT-116 cells and tumor growth. AGI-43192 can be used to study the role of SAM regulation in the central nervous system (CNS) and colon cancer[1].