Bexotegrast
Catalogue number:
HY-137561-100mg
Supplier:
Size:
100 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2376257-44-0
Purity:
99.74
Molecular Formula:
C27H36N6O3
Molecular Weight:
492.61
Mass Spectrometry:
Reference Materials
Alternative Names:
PLN-74809
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Bexotegrast (PLN-74809) is an orally active, potent dual αvβ6/αvβ1 integrin inhibitor with Kd of 5.7 nM and 3.4 nM, respectively. Bexotegrast inhibits αvβ6- and αvβ1-induced TGF-β activation with IC50 values of 29.8 nM and 19.2 nM, respectively. Bexotegrast has antifibrogenic effects and block multiple avenues of TGF-β activation in the fibrotic lung[1][2].