VH285-PEG4-C4-Cl
Catalogue number:
HY-111997-5mg
Supplier:
Size:
5 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1799506-07-2
Purity:
98.0
Molecular Formula:
C41H55ClN4O8S
Molecular Weight:
799.42
Mass Spectrometry:
Reference Materials
Alternative Names:
HaloPROTAC 3
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- MSDS: View or download
- Protocol: View or download
Product Description:
VH285-PEG4-C4-Cl (HaloPROTAC 3) is a conjugate of ligands for E3 and 16-atom-length linker. The connector of linker is Halogen group. VH285-PEG4-C4-Cl incorporates the VH285 based VHL ligand and an alkyl/ether-based linker. VH285-PEG4-C4-Cl is a highly potent and efficacious degrader of GFP-HaloTag7 with a DC50 of 19 nM. VH285-PEG4-C4-Cl is able to induce 90 % degradation of GFP-Halotag at 625 nM. VH285-PEG4-C4-Cl binds to VHL with an IC50 of 0.54 µM[1].