Cevidoplenib
Catalogue number:
HY-109082-10mg
Supplier:
Size:
10 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1703788-21-9
Purity:
99.58
Molecular Formula:
C25H27N7O3
Molecular Weight:
473.53
Mass Spectrometry:
Reference Materials
Alternative Names:
SKI-O-703
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Cevidoplenib (SKI-O-703) is an orally available inhibitor of spleen tyrosine kinase (Syk), with potential anti-inflammatory and immunomodulating activities. Cevidoplenib is also the mesylate form of SKI-O-592. Cevidoplenib and SKI-O-592 inhibits BCR-mediated survival, proliferation, and differentiation of B cells. And SKI-O-592 potently inhibits multiple kinases with IC50s of 6.2 nM (Syk), 1.859 µM (Jak2), 5.807 µM (Jak3), 0.412 µM (RET), 0.687 µM (KOR), 1.783 µM (FLT3), 16.96 µM (FGFR1), 5.662 µM (FGFR3), and 0.709 µM (Pyk2), respectively[1][2][3].