PODS Human CCL4

The product contains the polyhedrin protein co-crystalized with Human CCL4. A member of the CC sub-family of chemokines, CCL4 signals via the chemokine receptor CCR5. It plays a role in inflammation by attracting natural killer cells, monocytes, dendritic cells and lymphocytes to sites of injury. CCL4 is also one of the major HIV-suppressive factors produced by CD8+ T cells. It’s ability to bind CCR5 inhibits the cellular entry of M-tropic HIV strains, which utilise CCR5 as a co-receptor, in addition to downregulating CCR5 surface expression. It is secreted by numerous other cell types including neutrophils, monocytes, B cells, fibroblasts, endothelial cells and epithelial cells. Mature human CCL4 shares 77% and 80% aa sequence identity with mouse and rat CCL4, respectively.

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