Tesevatinib
Catalogue number:
HY-13314-5mg
Supplier:
Size:
5 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
781613-23-8
Purity:
99.41
Molecular Formula:
C24H25Cl2FN4O2
Molecular Weight:
491.39
Mass Spectrometry:
Reference Materials
Alternative Names:
XL-647; EXEL-7647; KD-019
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Tesevatinib (XL-647) is an orally available, blood-brain barrier-penetrant inhibitor of the epidermal growth factor receptor (EGFR). Tesevatinib significantly reduces cellular viability, with IC50 values of 11 nM and 102 nM in GBM12 and GBM6, respectively. Tesevatinib also inhibits HER2 (IC50=16.1 nM), VEGFR2 (IC50=1.5 nM), and Src (IC50=10.3 nM). Tesevatinib can inhibit tumor proliferation and exhibits antitumor activity[1][2].