Vorasidenib
Catalogue number:
HY-104042-2mg
Supplier:
Size:
2 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1644545-52-7
Purity:
99.87
Molecular Formula:
C14H13ClF6N6
Molecular Weight:
414.74
Mass Spectrometry:
Reference Materials
Alternative Names:
AG-881
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- MSDS: View or download
- Protocol: View or download
Product Description:
Vorasidenib (AG-881) is an orally available, brain penetrant second-generation dual mutant isocitrate dehydrogenases 1 and 2 (mIDH1/2) inhibitor. Vorasidenib (AG-881) exhibits nanomolar inhibition of (D)-2-hydroxyglutarate (D-2-HG), and the IC50 ranges of 0.04~22 nM against IDH1 R132C, IDH1 R132G, IDH1 R132H and IDH1 R132S and 7~14 nM against IDH2 R140Q and 130 nM against IDH2 R172K. Vorasidenib can be used for the study of grade 2 astrocytoma or oligodendroglioma with a susceptible IDH1/2 mutation[1][2].