CXCR2-IN-2
Catalogue number:
HY-120878-50mg
Supplier:
Size:
50 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1838123-21-9
Purity:
99.52
Molecular Formula:
C18H23ClN2O5S
Molecular Weight:
414.90
Mass Spectrometry:
Reference Materials
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
CXCR2-IN-2 is a selective, brain penetrant, and orally bioavailable CXCR2 antagonist (IC50=5.2 nM/1 nM in β-arrestin assay/CXCR2 Tango assay, respectively). CXCR2-IN-2 displays ~730-fold selectivity over CXCR1 and >1900-fold selectivity over all other chemokine receptors. CXCR2-IN-2 inhibits human whole blood Gro-α induced CD11b expression with an IC50 of 0.04 µM[1].