Lesogaberan (hydrochloride)
Catalogue number:
HY-10061B-25mg
Supplier:
Size:
25 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2925644-17-1
Purity:
98.0
Molecular Formula:
C3H10ClFNO2P
Molecular Weight:
177.54
Mass Spectrometry:
Reference Materials
Alternative Names:
AZD-3355 (hydrochloride)
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- Protocol: View or download
Product Description:
Lesogaberan (AZD-3355) hydrochloride is a potent and selective GABAB receptor agonist with an EC50 of 8.6 nM for human recombinant GABAB receptor. The affinity (Kis) of Lesogaberan hydrochloride for rat GABAB and GABAA receptors, as measured by displacement of [3H]GABA binding in brain membranes: 5.1 nM and 1.4 µM, respectively. Lesogaberan hydrochloride inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action[1].