D927
Catalogue number:
HY-128574-25mg
Supplier:
Size:
25 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2253733-37-6
Purity:
99.46
Molecular Formula:
C23H21FN4O3S
Molecular Weight:
452.50
Mass Spectrometry:
Reference Materials
Alternative Names:
DS11252927
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
D927 (DS11252927) is an orally active glucose transporter type 4 (GLUT4) translocation activator with an EC50 of 0.14 µM. D927 enhances the binding affinity of PI3Kα catalytic subunit p110α to canonical RAS proteins (KRAS4A, KRAS4B) and RRAS, RRAS2, MRAS. D927 activates the PI3Kα-AKT pathway (increasing phosphorylation of AKT, p70S6 kinase) without affecting the RAF-ERK1/2 pathway. D927 improves hyperglycemia in type 1 and type 2 diabetes mice model. D927 can be used for the study of glucose homeostasis disorders and diabetes[1][2].