Tesirine
Catalogue number:
HY-128952-1mg
Supplier:
Size:
1 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1595275-62-9
Purity:
98.31
Molecular Formula:
C75H101N9O23
Molecular Weight:
1496.65
Alternative Names:
SG3249
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Tesirine (SG3249) is an antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. Tesirine combines potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. SG3199 (HY-101161) is the released warhead component of the ADC payload Tesirine. SG3199 retains picomolar activity in a panel of cancer cell lines. PBD dimers are highly efficient DNA minor groove cross-linking agents with potent cytotoxicity[1][2].