BI-2852
Catalogue number:
HY-126247-1ml
Supplier:
Size:
1 ml
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2375482-51-0
Purity:
99.57
Molecular Formula:
C31H28N6O2
Molecular Weight:
516.59
Mass Spectrometry:
Reference Materials
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) by structure-based agent design with nanomolar affinity. BI-2852 is mechanistically distinct from covalent KRASG12C inhibitor (binds to switch II pocket) and binds ten-fold more strongly to active KRASG12D versus KRASwt (740 nM vs 7.5 µM). BI-2852 blocks GEF, GAP, and effector interactions with KRAS, leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells. 10mM