Rheb inhibitor NR1
Catalogue number:
HY-124798-1mL
Supplier:
Size:
1 ml
Product is available in:
£315.00
Special price until 31 Dec 2025
Normal price £350.00
Shipping is calculated in checkout
Normal price £350.00
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2216763-38-9
Purity:
99.46
Molecular Formula:
C25H19BrCl2N2O3S
Molecular Weight:
578.3
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- Protocol: View or download
Product Description:
Rheb inhibitor NR1 is a Rheb inhibitor with an IC50 of 2.1 µM in the Rheb-IVK assay. Rheb inhibitor NR1 can directly bind Rheb in the switch II domain and selectively inhibit the activation of mechanistic target of rapamycin complex 1 (mTORC1). Rheb inhibitor NR1 inhibits the phosphorylation of mTORC1 driven T389pS6K1 and increases the phosphorylation of S473pAKT in a dose-dependent manner. Rheb inhibitor NR1 does not influence mTORC2 activity[1]. (Rheb-IVK: Rheb-dependent mTORC1 kinase activity)