Laduviglusib (monohydrochloride)
Catalogue number:
HY-10182A-100mg
Supplier:
Size:
100 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1797989-42-4
Purity:
99.93
Molecular Formula:
C22H19Cl3N8
Molecular Weight:
501.80
Mass Spectrometry:
Reference Materials
Alternative Names:
CHIR-99021 (monohydrochloride); CT99021 (monohydrochloride)
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- MSDS: View or download
- Protocol: View or download
Product Description:
Laduviglusib (CHIR-99021) monohydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib monohydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib monohydrochloride is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib monohydrochloride enhances mouse and human embryonic stem cells self-renewal. Laduviglusib monohydrochloride induces autophagy[1][2][3].