Lometrexol (hydrate)
Catalogue number:
HY-14521B-5mg
Supplier:
Size:
5 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1435784-14-7
Purity:
99.20
Molecular Formula:
C21H27N5O7
Molecular Weight:
461.47
Mass Spectrometry:
Reference Materials
Alternative Names:
DDATHF (hydrate)
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Lometrexol (DDATHF) hydrate, an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol hydrate can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol hydrate has anticancer activity. Lometrexol hydrate also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor[1][2][3].