(R)-CR8 (trihydrochloride)
Catalogue number:
HY-18340A-5mg
Supplier:
Size:
5 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1786438-30-9
Purity:
98.95
Molecular Formula:
C24H32Cl3N7O
Molecular Weight:
540.92
Mass Spectrometry:
Reference Materials
Alternative Names:
CR8, (R)-Isomer (trihydrochloride)
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
(R)-CR8 (CR8) trihydrochloride, a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor. (R)-CR8 trihydrochloride inhibits CDK1/cyclin B (IC50=0.09 µM), CDK2/cyclin A (0.072 µM), CDK2/cyclin E (0.041 µM), CDK5/p25 (0.11 µM), CDK7/cyclin H (1.1 µM), CDK9/cyclin T (0.18 µM) and CK1δ/ε (0.4 µM). (R)-CR8 trihydrochloride induces apoptosis and has neuroprotective effect[1][2]. (R)-CR8 trihydrochloride acts as a molecular glue degrader that depletes cyclin K[3].