£676.00
Estimated delivery Tue 7 May
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
821768-06-3
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
419.3
Alternative Names:
4-[3-(trifluoromethyl)-2-pyridinyl]-n-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide
- Data sheet: View or download
- MSDS: View or download
Product Description:
A TRPV1 antagonist (Ki = 72 nM for the recombinant guinea pig channel); inhibits capsaicin- or pH decrease-induced guinea pig TRPV1 channel activation (IC50s = 58 and 470 nM, respectively); reduces the number of citric acid- or capsaicin-induced coughs in guinea pigs at 20 mg/kg; reduces spontaneous and palpitation-induced flinching and guarding in a mouse model of bone cancer pain at 30 mg/kg; decreases capsaicin-induced production of CGRP and inflammatory soup-induced trigeminal expression of cfos in rat models of migraine
Storage Temperature:
-20°C