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DNA/RNA Shield reagent

The DNA/RNA Shield™ reagent from Zymo Research is a DNA and RNA stabilisation solution which preserves the genetic integrity and expression profiles of samples at ambient temperatures, whilst completely inactivating infectious agents (viruses, bacteria, fungi and parasites). This unique solution also prevents degradation from freeze-thaw cycling and unexpected freezer failures, allowing ambient temperature shipping.

Available as a 2X concentrate or as a ready to use mix, DNA/RNA Shield is compatible with any custom collection devices.

Benefits of using DNA/RNA Shield
• No reagent removal required prior to nucleic acid purification
• Pathogen inactivation
• RNA stable at room temperature for one month
• DNA stable at room temperature for two years
• RNA and DNA stored at -20C is stable indefinitely

DNA/RNA Shield: complete pathogen inactivation
DNA/RNA Shield has been rigorously tested to ensure its capability to inactive even the toughest of viruses. In an independent study, the virucidal activity was shown to inactivate murine parvovirus1. DNA/RNA Shield abides by the Center for Disease Control’s (CDC) guidelines for pathogen inactivation2.

DNA/ RNA Shield effectively inactivates pathogens. This includes tough-to-lyse microbes or viruses without the need for additional steps, such as heat-treatment, homogenisation, or alcohol sterilisation. DNA/RNA Shield has been rigorously tested to ensure inactivation of pathogens including:

B. subtilis, E. faecalis, E. coli, L. fermentum, L. monocytogenes, M. tuberculosis, P. aeruginosa, S. enterica, S. aureus, S. pneumoniae, X. fastidiosa

Parvovirus, Chikungunya virus , Dengue virus, Ebola virus, Herpes simplex virus-1, Herpes simplex virus-2, Influenza A, Rhinovirus, MERS-coronavirus, West Nile virus 

Yeast & eukaryotes 
C. albicans , C. neoformans , S. cerevisiae , P. malariae

1. Dr. Thraenhart and Dr. Jursch. Virucidal activity of the nucleic acid preservation product “DNA/RNA Shield™” against the murine parvovirus (MVM) at 20 °C. 
2. Guidance on the inactivation or removal of select agents and toxins for future use. Center for Disease Control (CDC)

Material available for download
DNA/RNA Shield protocol

Free samples
Request a free DNA/RNA Shield sample

Zymo Research has filed for Emergency Use Authorisation (EUA) w/ the FDA for its collection, extraction, and RT-PCR workflow for COVID-19 Testing.


Note: product availability depends on country - see product detail page.

Details Cat number & supplier Size Price
DNA/RNA Shield (2X Concentrate) R1200-25 · Zymo Research
Zymo Research
25 ml £78.00
25 ml
DNA/RNA Shield R1100-50 · Zymo Research
Zymo Research
50 ml £82.00
50 ml
DNA/RNA Shield (2X Concentrate) R1200-125 · Zymo Research
Zymo Research
125 ml £271.00
125 ml
DNA/RNA Shield R1100-250 · Zymo Research
Zymo Research
250 ml £281.00
250 ml
DNA/RNA Shield R1100-1L-PUR · Zymo Research
Zymo Research
1000 ml £868.00
1000 ml