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RNA & DNA preservation: DNA/RNA Shield

DNA/RNA Shield from Zymo Research is a DNA and RNA transport and stabilisation solution for nucleic acids in any biological sample. DNA/RNA Shield preserves the genetic integrity and expression profiles of samples at ambient temperatures and completely inactivates infectious agents (viruses, bacteria, fungi, & parasites). This unique DNA and RNA stabilisation solution also prevents degradation from freeze-thaw cycling and unexpected freezer failures.

Benefits of using DNA/RNA Shield
• Prefilled devices, bulk reagents and custom fills available
• CE-IVD and RUO formats available
• Preserves RNA integrity
• Deactivates pathogens (viruses, bacteria, fungi and parasites)
• Safe, room temperature, shipping and handling
• Compatible with most RNA extraction kits, without reagent removal
• In use in numerous NHS and private testing labs in the UK and globally

Nucleic acid stabilisation without cold chain

Nucleic acid stabilisation without cold chain

 Prefilled devices, bulk reagent and customs fills available

Sample type/device
DNA/RNA Shield Reagent
Faecal collection tube
Swab collection tube
Blood collection tube
Saliva collection kit
Lysis tubes
Urine conditioning buffer
Swab samples
Environmental samples
Vector (tissue and insect)

Complete pathogen inactivation
DNA/RNA Shield has been rigorously tested for its ability to deactivate a wide range of pathogens, including MERS coronavirus, Ebola and M. tuberculosis, without the need for additional steps, such as heat-treatment, homogenisation or alcohol sterilisation. In an independent study, the virucidal activity was shown to inactivate murine parvovirus1. DNA/RNA Shield abides by the Center for Disease Control’s (CDC) guidelines for pathogen inactivation2.

Inactivation of SARS-CoV-2 with DNA/RNA Shield

Pathogen type Species inactivated
Viruses MERS-coronavirus, Parvovirus, Chikungunya virus, Dengue virus, Ebola virus, Herpes simplex virus-1, Herpes simplex virus-2, Influenza A, Rhinovirus, West Nile virus
Bacteria B. subtilis, E. faecalis, E. coli, L. fermentum, L. monocytogenes, M. tuberculosis, P. aeruginosa, S. enterica, S. aureus, S. pneumoniae, X. fastidiosa
Yeast and eukaryotes C. albicans , C. neoformans , S. cerevisiae , P. malariae


1. Dr. Thraenhart and Dr. Jursch. Virucidal activity of the nucleic acid preservation product “DNA/RNA Shield™” against the murine parvovirus (MVM) at 20 °C. 
2. Guidance on the inactivation or removal of select agents and toxins for future use. Center for Disease Control (CDC)

Zymo Research COVID antigen testing FDA EUA workflow
DNA/RNA Shield is a key component of the Zymo Research COVID antigen testing workflow, which has been granted an EUA by the FDA. More information can be found here.

Material available for download
DNA/RNA Shield: For safe, effective COVID-19 surveillance
DNA/RNA Shield swab collection kit protocol
DNA/RNA Shield protocol
Eurovir® DNA/RNA Shield test report
DNA/RNA Shield inactivation citations
DNA/RNA Shield COVID-19 inactivation declaration
Inactivation of SARS-CoV-2 with DNA/RNA Shield
DNA/RNA Shield Lysis Tube protocol
DNA/RNA Shield Lysis & Collection Tubes recommended purification kits

Free samples
Request a free DNA/RNA Shield sample

DNA/RNA shield, DNA RNA shield, sample collection, sample preservation, RNAlater, RNA later


Note: product availability depends on country - see product detail page.

Details Cat number & supplier Size Price
DNA/RNA Shield R1100-50 · Zymo Research
Zymo Research
50 ml £91.00
50 ml
DNA/RNA Shield R1100-250 · Zymo Research
Zymo Research
250 ml £318.00
250 ml
DNA/RNA Shield R1100-1L-PUR · Zymo Research
Zymo Research
1000 ml £842.00
1000 ml
DNA/RNA Shield (2X Concentrate) R1200-25 · Zymo Research
Zymo Research
25 ml £85.00
25 ml
DNA/RNA Shield (2X Concentrate) R1200-125 · Zymo Research
Zymo Research
125 ml £299.00
125 ml
DNA/RNA Shield Lysis Tube w/ Swab (0.1 & 0.5 mm) (Microbe) R1104 · Zymo Research
Zymo Research
50 pack £395.00
50 pack
DNA/RNA Shield Lysis Tube (2 mm) (Tissue) R1105 · Zymo Research
Zymo Research
50 pack £329.00
50 pack
DNA/RNA Shield Collection Tube R1102 · Zymo Research
Zymo Research
50 pack £263.00
50 pack
DNA/RNA Shield Blood Collection Tube R1150 · Zymo Research
Zymo Research
50 pack £592.00
50 pack
DNA/RNA Shield Fecal Collection Tube R1101 · Zymo Research
Zymo Research
10 pack £120.00
10 pack
DNA/RNA Shield Lysis Tubes (0.1 & 0.5 mm) (Microbe) R1103 · Zymo Research
Zymo Research
50 pack £329.00
50 pack