Rimonabant
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168273-06-1
≥98%
A crystalline solid
C22H21Cl3N4O
463.8
5-
- MSDS: View or download
A CB1 receptor antagonist (Ki = 5.6 nM); selective for CB1 over CB2 receptors (Ki = >1,000 nM), as well as a panel of 37 other receptors and channels (IC50s = >1,000 nM); inhibits phytohemagglutinin-induced proliferation of isolated human PBMCs at 10 µM; prevents (+)-WIN 55,212-2-induced decreases in body temperature and increases in tail-flick latency in mice (ED50s = 0.28 and 1.62 mg/kg, i.p.); reduces body weight in a mouse model of diet-induced obesity at 10 mg/kg in the drinking water; decreases the percentage of time spent in the open arms of the elevated plus maze in mice, indicating anxiety-like activity, at 10 mg/kg
