Ro 08-2750
Catalogue number:
CAY28772-1 mg
Supplier:
Size:
1 mg
Product is available in:
£52.00
Estimated delivery Mon 29 Dec
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
37854-59-4
Purity:
≥95%
Formulation:
A solid
Molecular Formula:
C13H10N4O3
Molecular Weight:
270.24366
Alternative Names:
2,3,4,10-
Product Description:
A p75NTR ligand; completely inhibits NGF binding to p75NTR in PC12 cells at 100 µM; binds to NGF dimers (Kd = ~1 µM) to induce a conformational change that prevents NGF binding to p75NTR or TrkA; inhibits NGF-induced death of SK-N-MC cells and inhibits autophosphorylation of TrkA in PC12 cells; reverses NGF-induced decreases in β-catenin mRNA expression in, and migration of, SKOV3 and OVCAR-3 ovarian cancer cells
