Ro 08-2750
Catalogue number:
CAY28772-1 mg
Supplier:
Size:
1 mg
Product is available in:
£52.00
Estimated delivery Mon 1 Jun
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
37854-59-4
Purity:
≥95%
Formulation:
A solid
Molecular Formula:
C13H10N4O3
Molecular Weight:
270.24366
Alternative Names:
2,3,4,10-
Product Description:
A p75NTR ligand; completely inhibits NGF binding to p75NTR in PC12 cells at 100 µM; binds to NGF dimers (Kd = ~1 µM) to induce a conformational change that prevents NGF binding to p75NTR or TrkA; inhibits NGF-induced death of SK-N-MC cells and inhibits autophosphorylation of TrkA in PC12 cells; reverses NGF-induced decreases in β-catenin mRNA expression in, and migration of, SKOV3 and OVCAR-3 ovarian cancer cells
