CK-666

An Arp2/3 inhibitor (IC50s = 4, 17, and 5 µM for the human, bovine, and S. pombe complexes, respectively, in an actin polymerization assay); binds at the Arp2/3 interface, stabilizing the inactive conformation of the complex; inhibits actin comet tail formation around intracellular L. monocytogenes in infected SKOV3 cells at 40 µM; induces actin remodeling, inhibits lamellipodia formation, and reduces the motility rate in M-1 epithelial cells at 200 µM; impairs long-term fear memory formation in rats when microinjected into the lateral amygdala at 100 µM