Eact

An ANO1 channel activator; increases chloride currents in FRT cells expressing human ANO1 (EC50 = 3 µM); selective for ANO1 over CFTR and ENaCs in FRT cells at 10 µM; increases the rate of submucosal gland fluid secretion in human bronchi isolated from patients with cystic fibrosis and healthy individuals at 20 µM; increases production of mitochondrial ROS, reduces the mitochondrial membrane potential, and induces apoptosis in RLMVECs; reduces total cell counts in pulmonary artery endothelial cell populations isolated from patients with IPAH; activates TRPV1 in HEK293T cells expressing the mouse receptor (EC50 = 11.6 µM); induces scratching and licking behaviors in wild-type, but not Trpv1-/-, mice