Rotenone
Shipping is calculated in checkout
83-79-4
≥95%
A crystalline solid
C23H22O6
394.4
(2r,6as,12as)-
An inhibitor of mitochondrial complex I; inhibits NADH/DB oxidoreductase and NADH oxidase (IC50s = 28.8 and 5.1 nM, respectively); increases ROS production in the mitochondria of substantia nigra pars compacta neurons; induces Parkinson-like neuropathology and behavior in rodents; reduces tyrosine hydroxylase levels in the posterior striatum and prefrontal cortex, induces catalepsy, and decreases spontaneous locomotion and exploration in the open field test in rats at 1.5 and 2.5 mg/kg per day for two months; commonly used as a model of Parkinson’s in rodents
