Nepodin

A naphthol with diverse biological activities; inhibits COX-1 and COX-2 in vitro (IC50s = 27.43 and 32.28 µM, respectively); inhibits C. albicans and S. aureus biofilm formation from 1-10 µM; active against chloroquine-sensitive and -resistant P. falciparum strains (IC50s = 0.74 and 0.79 µg/ml for strains 3D7 and S20, respectively); suppresses parasitemia and increases survival time in a mouse model of P. berghei infection at 250 mg/kg; increases skeletal muscle phosphorylation of AMPK, reduces serum and hepatic triglyceride and cholesterol levels, and improves insulin resistance in db/db diabetic mice