Rivenprost
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256382-08-8
≥98%
A 1 mg/ml solution in methyl acetate
C24H34O6S
450.6
4-[[2r-[3r-hydroxy-2-[3s-hydroxy-4-[3-(methoxymethyl)phenyl]-1r-buten-1e-yl]-5-oxocyclopentyl]ethyl]thio]-butanoic acid, methyl ester, 16-(3-methoxymethyl)phenyl-ω-tetranor-5-thiapge1 methyl ester, ono-4819, ono-ae1-734
An EP4 receptor agonist (Kis = 0.7, 56, 620, and >10,000 nM, respectively, as the free acid); enhances bone morphogenic protein-induced increases in alkaline phosphatase activity in primary mouse calvarial osteoblasts at 100 nM; decreases LPS-induced increases in plasma TNF-α levels in rats; decreases trabecular separation, as well as increases bone volume, in rats at 10 µg/kg; increases proximal tibiae biomechanical strength in ovariectomized rats at 3 and 10 mg/kg
