Selank (acetate)

A synthetic derivative of the tetrapeptide tuftsin that contains a Pro-Gly-Pro sequence at the C-terminus; increases the amplitude and discharge rate of inhibitory postsynaptic currents of neurons in the rat hippocampal CA1 region at 1 µM; decreases the level of affective responses and the number of erroneous escape attempts in rats in an acute stress situation, increases orientational-investigative responses of rats in an unfamiliar situation, and reduces the time mice spend immobile in the forced swim test; increases locomotor activity of high-anxiety Balb/c, but not C57Bl/6, mice in the open field test; decreases apomorphine-induced verticalization in mice at 0.01 mg/kg; decreases expression of the inflammation-related genes Il2rg and Xcr1 in mouse spleen after 90 minutes at 100 µg/kg