TMI-005
Catalogue number:
CAY29016-1 mg
Supplier:
Size:
1 mg
Product is available in:
£62.00
Estimated delivery Mon 13 Apr
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
287405-51-0
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C17H22N2O6S2
Molecular Weight:
414.49846
Alternative Names:
(3s)-n-
Product Description:
An inhibitor of ADAM17/TACE, MMP-1, and MMP-13 (IC50s = 20, 33, and 8.1 nM, respectively); inhibits LPS-induced TNF-α release in isolated human whole blood (IC50 = 144 ng/ml); reduces basal and ionizing radiation-induced secretion of ALCAM and amphiregulin from A549 and NCI H125 cells at 25 µM; inhibits proliferation of A549 at 25 and 50 µM; sensitizes A549 and NCI H125 cells to ionizing radiation at 25 µM; reduces tumor growth in an A549 mouse xenograft model when administered at 25 mg/kg twice per day in combination with ionizing radiation
