Gefitinib-based PROTAC 3
Catalogue number:
CAY28597-10 mg
Supplier:
Size:
10 mg
Product is available in:
£193.00
Estimated delivery Wed 15 Apr
Shipping is calculated in checkout
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2230821-27-7
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C47H57ClFN7O8S
Molecular Weight:
934.514963
Alternative Names:
(2s,4r)-1-((s)-
Product Description:
A PROTAC comprised of gefitinib linked to VHL ligand 1; induces degradation of EGFR containing the activating mutation L858R or an exon 19 deletion (DC50s = 22.3 and 11.7 nM, respectively) but does not induce degradation of wild-type EGFR at ≤10 µM in cell-based assays
