PCI-29732
Catalogue number:
CAY29036-25 mg
Supplier:
Size:
25 mg
Product is available in:
£743.00
Estimated delivery Wed 18 Feb
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
330786-25-9
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C22H21N5O
Molecular Weight:
371.43524
Alternative Names:
1-
Product Description:
A multi-kinase inhibitor; inhibits BTK, LCK, and LYN (Kis = 8.2, 4.6, and 2.5 nM, respectively), as well as the activity of three receptor tyrosine kinases and seven non-receptor tyrosine kinases by greater than 90% in a panel of over 100 kinases at 10 µM; inhibits calcium flux in Ramos B cells and phosphorylation of PLCɣ1 (IC50s = 0.53 and 0.33 µM, respectively); cytotoxic to S1-MI-80, H460/MX20, and KBv200 cancer cells overexpressing the ATP-binding cassette transporter (IC50s = 7.8, 6.3, and 6.02 µM, respectively); in combination with topotecan, reduces tumor growth in an H460/MX20 mouse xenograft model at 20 mg/kg
