Thymosin α1 (human, mouse, rat, bovine)

An immunomodulator peptide formed from the cleavage of prothymosin α; inhibits the growth of 5TGM1 mouse and OPM-2, LP-1, and U266 human multiple myeloma cells in vitro but not in vivo; increases CD3- and CD28-induced T cell proliferation in C57BL/KaLwRij splenocytes but not in allogeneic mixed lymphocyte reactions using C57BL/KaLwRij and BALB/c splenocyte co-cultures at 20 µM; inhibits the growth and migration of H1299, NL9980, and L9981 NSCLC cells that express high PD-L1 levels but not of A549 and SPC-A-1 NSCLC cells that express low PD-L1 levels; decreases the number of metastatic lesions in a L9981, but not an A549, NSCLC mouse xenograft model at 20 mg/kg per day; increases IDO1 expression and IL-10 levels and decreases IL-1β and TNF-α production in the lung in a CFTRF508del/F508del mouse model of cystic fibrosis and chronic A. fumigatus infection at 200 µg/kg