(±)11-HDHA

Name: (±)11-HDHA
Brand: Cayman Chemical
SKU: CBSKU_00098829
Price: 839 GBP
Availability: InStock

Catalogue number:

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CAY33450-250 ug

Supplier:

Cayman Chemical

Size:

250 µg

Product is available in:

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£839.00

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Estimated delivery Wed 7 Jan
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This product is for research use only and is not for human consumption or therapeutic use.

CAS Number:

87018-59-5

Purity:

≥98%

Formulation:

A solution in ethanol

Molecular Formula:

C22H32O3

Molecular Weight:

344.5

Alternative Names:

(±)11-hydroxy-4z,7z,9e,13z,16z,19z-docosahexaenoic acid, (±)11-hdohe, 11-hydroxy docosahexaenoic acid

Product Description:

(±)11-HDHA is an autoxidation product of DHA in vitro.{7479,7491} It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes.{7480,7490,7492} DHA is metabolized to 11(S)-HDHA by human platelets and canine retina.{7483,7486,7484,7492} In addition to 11(S)-HDHA, 14(S)-HDHA is also produced by platelets.{7483,7484,7492} 11(S)-HDHA is an inhibitor of U-46619-induced human platelet aggregation and rabbit and rat aortic smooth muscle contraction with IC50 values of about 50, 4.7, and 7.5 µM, respectively.{7484,7481} (±)11-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant PUFA.