12(S)-HEPE
Catalogue number:
CAY32550-25 ug
Supplier:
Size:
25 µg
Product is available in:
£214.00
Estimated delivery Wed 22 Apr
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
116180-17-7
Purity:
≥98%
Formulation:
A 100 µg/ml solution in ethanol
Molecular Formula:
C20H30O3
Molecular Weight:
318.5
Alternative Names:
12s-
Product Description:
12(S)-HEPE is a monohydroxy fatty acid synthesized from EPA by the action of 12-LO. Unstimulated neutrophils metabolize 12(S)-HEPE to 12(S),20-diHEPE, whereas stimulated neutrophils produce 5(S),12(S)-HEPE via the 5-lipoxygenase pathway.{6402} The competitive action of 12(S)-HEPE with arachidonic acid as a substrate for 5-LO in the formation of leukotrienes may provide a basis for the anti-inflammatory potential of ω-3 fatty acids.
