RIPGBM
Catalogue number:
CAY27860-1 mg
Supplier:
Size:
1 mg
Product is available in:
£121.00
Estimated delivery Wed 10 Jun
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
355406-76-7
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C26H21FN2O3
Molecular Weight:
428.455023
Alternative Names:
n-[1,4-dihydro-
Product Description:
A prodrug form of the pro-apoptotic compound cRIPGBM; converted to cRIPGBM in GBM-1 GBM CSCs but not primary HLFs; induces apoptosis in GBM CSCs (EC50 = ≤500 nM); selectively reduces survival of GBM-1 cells (EC50 = 0.22 µM) over human neural stem cells, primary human astrocytes, and primary HLF cells (EC50s = 1.7, 2.9, and 3.5 µM, respectively); reduces tumor growth in a GBM mouse xenograft model using patient-derived GBM-39 cells engineered to express IRFP720 at 50 mg/kg twice per day
