GHRP-6 (acetate)
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145177-42-0
≥98%
A crystalline solid
C46H56N12O6 • 3C2H4O2
1053.17
l-histidyl-d-tryptophyl-l-alanyl-l-tryptophyl-d-phenylalanyl-l-lysinamide, triacetate, growth hormone releasing peptide 6, hexapeptide-2, hwawfk-nh2, skf 110679, u 75799e
A synthetic GH secretagogue and an agonist of GHS-R; inhibits binding of the GHS-R agonist MK-0677/ibutamoren (Ki = 1.9 nM) and ghrelin (Kd = 260 nM) to GSH-R type Ia and GSH-R, respectively; stimulates intracellular calcium mobilization (EC50 = 4.5 nM) and inositol phosphate production (EC50 = 0.83 nM) in cells expressing the human receptor; negative allosteric modulator of ghrelin signaling; induces release of GH, but not TSH, LH, or FSH, in isolated rat pituitary gland at 0.03 µg/ml; increases levels of GH, but not TSH, LH, FSH, or prolactin, in rat blood at 50 µg; increases food intake in rats at 0.3, 1, and 3 nmol
