17(R)-Resolvin D3
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1427475-53-3
≥90%
A solution in ethanol
C22H32O5
376.48648
(4s,5z,7e,9e,
- MSDS: View or download
An aspirin-triggered epimer of resolvin D3; has been found in mouse inflammatory exudates; reduces transmigration of neutrophils into the peritoneal cavity, as well as decreases the levels of IL-6 and increases the levels of IL-10 in inflammatory exudate in a mouse model of zymosan-induced peritonitis at 10 ng/animal; activates GPR32 in a β-arrestin reporter assay and increases phagocytosis to a greater degree in CHO cells overexpressing GPR32 compared to mock-transfected cells; increases phagocytosis of etoposide-generated tumor cell debris by monocyte-derived macrophages in H460 human lung carcinoma cells in a concentration-dependent manner; inhibits tumor growth in a mouse model of Lewis lung carcinoma at 0.6 µg/kg per day
