AZD 3229
Catalogue number:
CAY27908-1 mg
Supplier:
Size:
1 mg
Product is available in:
£181.00
Estimated delivery Wed 15 Apr
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2248003-60-1
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C24H26FN7O3
Molecular Weight:
479.507023
Alternative Names:
n-[4-[[5-fluoro-
Product Description:
An inhibitor of c-Kit-driven cell proliferation; selectively inhibits growth of c-Kit mutant (GI50s = 1-971 nM) and PDGFR mutant (GI50s = 1-22 nM) Ba/F3 cell lines over Ba/F3 cell lines expressing Tel-KDR/VEGFR2 (GI50 = 1,378 nM); induces tumor regression in a Ba/F3 mouse xenograft model at 20 mg/kg per day; induces tumor regression in a mouse allograft model using Ba/F3 cells expressing KIT-exon 11 del/V654A at 20 mg/kg twice per day
