Setipiprant
Catalogue number:
CAY28291-50 mg
Supplier:
Size:
50 mg
Product is available in:
£481.00
Estimated delivery Fri 19 Sep
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
866460-33-5
Purity:
≥98%
Formulation:
A solid
Molecular Formula:
C24H19FN2O3
Molecular Weight:
402.417743
Alternative Names:
8-fluoro-1,2,3,4-tetrahydro-2-(1-naphthalenylcarbonyl)-5h-pyrido[4,3-b]indole-5-acetic acid, act-129968
Product Description:
An orally bioavailable antagonist of CRTH2/DP2 (IC50 = 6 nM for the human receptor); selective for CRTH2/DP2 over DP1 in a radioligand binding assay (IC50 = 1,290 nM) and EP2 and EP4 in a β-arrestin assay (IC50s = 2,600 and >10,000 nM, respectively); inhibits PGD2-induced calcium flux in HEK293 cells expressing human CRTH2/DP2 (IC50 = 30 nM); inhibits PGD2-induced shape change in human eosinophils (IC50 = 235 nM)
