Sodium Butyrate
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156-54-7
≥95%
A crystalline solid
110.1
butanoic acid, sodium salt, butyric acid, fa 4:0
- Data sheet: View or download
- MSDS: View or download
A short-chain fatty acid; produced predominately by bacterial fermentation of dietary fiber in the colon but has also been identified in mammalian milk; an HDAC inhibitor (IC50 = 90 µM in a cell-free assay); induces differentiation, cell cycle arrest at the G0 phase, and apoptosis, as well as inhibits proliferation, in a variety of cancer cells from 0.6-100 mM; decreases the expression of IFN-γ-related signaling genes and metastatic genes in H460 human lung cancer cells at 2 mM; reduces tumor growth in a CaSki mouse xenograft model at 200 and 800 mg/kg per day; reduces increases in colonic TNFa and Il6 expression and decreases colonic goblet cell depletion, tissue damage, muscle thickening, and cellular infiltration in a wild-type, but not Hcar2-/-, mouse model of TNBS-induced colitis
22°C
