1-Palmitoyl-2-hydroxy-sn-glycero-3-PC
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17364-16-8
≥98% (9:1 mixture of 1-acyl and 2-acyl)
A crystalline solid
C24H50NO7P
495.6
(7r)-4,7-di
Ubiquitous lipid species generated following PLA2 hydrolysis of phosphatidylcholine; increases the production of ROS and decreases SOD and eNOS protein levels and phosphorylation of ERK1/2 in HUVECs at 125 µM; potentiates the secretion of IL-6, IL-1β, IL-12, and TNF-α in LPS-stimulated M1 macrophages, but has no effect on CD163, CD206, CD36, or IL-10 in LPS-stimulated M2 macrophages at 0.3-1.0 µM; increases TGF-β1 production and enhances Foxp3 protein levels in Treg cells in isolated human peripheral blood at 10 µM; enhances neutrophil function, bacterial clearance, and survival in mouse models of sepsis at 10 mg/kg.
